ECHICETIN
Product ID L8123-50UG 
Name ECHICETIN 
Molecular formula A dimer of 256-amino acid: subunit α with 133-amino acid and subunit β with 123-amino acid
Description

It binds to platelet glycoprotein Iba and blocks von Willebrand factor (vWF) and Thrombin binding.

Echicetin inhibits aggregation of washed platelets induced by vWF, thrombin or alboaggregin-A. However, when complexed with the pentameric plasma immunoglobulin Mkappa (IgMκ), Echicetin binds specifically to GPIb and activates platelets


C-type lectin purified from Echis carinatus sochurecki venom
Biological activity

Echicetin can be used either to block GPlba functions or, if labelled with 125I or biotin or fluorescein isothiocyanate, to measure GPlba expression levels. In the presence of plasma, Echicetin agglutinates platelets via GPlba and lgM and can be used to assess GPlba expression levels directly, independently of vWF levels or function.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 187.00

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5 Unité(s) 748.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8123-50UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8123-50UG  Molecular weight 30 kDa: 16 kDa + 14 kDa
Product name ECHICETIN  Physical form A white solid film on the bottom of the vial
CAS No. 148937-32-0 Melting point
RTECS Solubility Water and saline buffer
UNIPROT P81017;P81996 Optical Activity
PubChem SID    
PubChem CID    
Purity > 99%    
Toxicity(LD50) Not investigated    
Chemical Name    
Storage & Reconstitution
Recommandations

Shipped at ambient temperature under lyophilized powder.
Store at -20°C (-4°F). Do not freeze-thaw.
Aliquot sample if required and store at -80°C (-112°F)
Reconstitution in saline solution


 
Savety Recommandations

For research use. Not for food, drug, household or other uses

 
 Bibliographic References
Product code L8123-50UG 
Product name ECHICETIN 

- Peng M, Hon JC, Niewiarowski S., Biochem Biophys Res Commun. 1994; 205: 68-72
- Peng M, Emig FA, Mao A, Lu W, Kirby EP, Niewiarowski S. Kowalska MA., Thromb Haemost. 1995; 74: 954-957
- Navdaev, A, and Clemetson, K.J.J. Biol. Chem. 2002; 277
- Navdaev A., Dormann D., Clemetson J.M., Clemetson K.J. Blood 97:2333-2341(2001)
- Polgar J., Magnenat E.M., Peitsch M.C., Wells T.N.C., Saqi M.S.A., Clemetson K.J., Biochem. J. 323:533-537(1997)
- Peng M., Lu W., Beviglia L., Niewiarowski S., Kirby E.P. Blood 81:2321-2328(1993)
 Links
Product code L8123-50UG 
Product name ECHICETIN 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
UNIPROT
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