L8201-100UG - CHARYBDOTOXIN
(Syn. : Potassium channel toxin alpha-KTx 1.1, ChTX, ChTX-Lq1, ChTx-a)
(Syn. : Potassium channel toxin alpha-KTx 1.1, ChTX, ChTX-Lq1, ChTx-a)
CHARYBDOTOXIN | Product ID | L8201-100UG |
| Name | CHARYBDOTOXIN |
| Molecular formula | C176H277N57O55S7 |
| Description |
37-amino acid peptide with 3 disulfide bridges , from Leiurus quinquestriatus scorpion venom |
| Biological activity | It is a blocker of large conductance Ca2+-activated potassium channels and other K+ channels. It causes hyperexcitability of the nervous system. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 119.00 | ||
| 5 Unité(s) | 476.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8201-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8201-100UG | Molecular weight | 4,296 Da |
| Product name | CHARYBDOTOXIN | Physical form | Powder |
| CAS No. | 95751-30-7 | Melting point | |
| RTECS | Solubility | Well in saline | |
| UNIPROT | P13487 | Optical Activity | No optical Activity |
| PubChem SID | |||
| PubChem CID | 56842037 | ||
| Purity | > 98 % (HPLC) | ||
| Toxicity(LD50) | ICE-MUS LD0: 40 µg/kg | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Charybdotoxin (native) is packaged under Argon and the amount of protein as determined by UV spectra was checked after repartition and lyophilisation by amino acid analysis. The mean variation percentage in weight is less than 5% compared to lyophilized Charybdotoxin |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8201-100UG |
| Product name | CHARYBDOTOXIN |
- Schweitz H, Bidard JN, Maes P, Lazdunski M. Charybdotoxin is a new member of the K+ channel toxin family that includes dendrotoxin I and mast cell degranulating peptide. Biochemistry. 1989 Dec 12;28(25):9708-14.
- Gimenez-Gallego G, Navia MA, Reuben JP, Katz GM, Kaczorowski GJ, Garcia ML. Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci U S A. 1988 May;85(10):3329-33.
- Sugg EE, Garcia ML, Reuben JP, Patchett AA, Kaczorowski GJ. Synthesis and structural characterization of charybdotoxin, a potent peptidyl inhibitor of the high conductance Ca2(+)-activated K+ channel. J Biol Chem. 1990 Nov 5;265(31):18745-8.
- Massefski W Jr, Redfield AG, Hare DR, Miller C. Molecular structure of charybdotoxin, a pore-directed inhibitor of potassium ion channels. Science. 1990 Aug 3;249(4968):521-4. Retraction in: Massefski W Jr, Redfield AG, Hare DR, Miller C. Science. 1991 May 3;252(5006):631.
Links
| Product code | L8201-100UG |
| Product name | CHARYBDOTOXIN |
| External Links |
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Toxicology Citations From PubMed
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