L6032 - IMPERIALINE (3-alpha-Chloro-)
(Syn. : 3-alpha-Chlorimperialine, 3-alpha-Chloro-3-deoxyimperialine)
(Syn. : 3-alpha-Chlorimperialine, 3-alpha-Chloro-3-deoxyimperialine)
IMPERIALINE (3-alpha-Chloro-) | Product ID | L6032 |
| Name | IMPERIALINE (3-alpha-Chloro-) |
| Molecular formula | C27H42CINO2 |
| Description |
It is a potent long-acting selective M2 muscarinic receptor antagonist, with a strong activity on the brain. Cervane alkaloid , derivative of Imperialine from the plant Petilium eduardi |
| Biological activity | 3-alpha-Chloro-Imperialine, a long-acting cholinoblocker of M2 receptors, blocks M2 receptors in the heart at 5 μg/kg (i.v.) and the action develops gradually. 3-alpha-Chloro-Imperialine's activity is more than 10 times higher than that of Imperialine and is specially high in the brain. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 x 1mg | 162.00 | ||
| 5 x 1mg | 648.00 | ||
| 5 mg | 648.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6032 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6032 | Molecular weight | 448.08 g/mol |
| Product name | IMPERIALINE (3-alpha-Chloro-) | Physical form | |
| CAS No. | 153720-48-0 | Melting point | 215-220 °C |
| RTECS | Solubility | In chloroform Not well in acetone, methanol, ethanol, water |
|
| UNIPROT | Optical Activity | ||
| PubChem SID | |||
| PubChem CID | 98047543 | ||
| Purity | 97% | ||
| Toxicity(LD50) | IVN-MUS LD50: 52 mg/kg | ||
| Chemical Name | Cevan-6-one,3-chloro-20-hydroxy-, (3alpha,5alpha,17beta)- (9CI) | ||
| Storage & Reconstitution Recommandations |
Store at +4°C, in dark place. |
||
| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
||
Bibliographic References
| Product code | L6032 |
| Product name | IMPERIALINE (3-alpha-Chloro-) |
- Eglen et al., "Characterisation of the interaction of the cervane alkaloid, imperialine, at Muscarinic receptors in vitro." Naunyn-Schmiedeberg’s Arch. Pharmacol. (1992) 346:144-151
- on 3-b-Bromo-Imperialine: Mirzaev, unbublished results.
Links
| Product code | L6032 |
| Product name | IMPERIALINE (3-alpha-Chloro-) |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
|
PubChem CID
|
|
