LATROTOXIN (Alpha-)
Product ID L8410 
Name LATROTOXIN (Alpha-) 
Molecular formula
Description

It is a presynaptic neurotoxin, specific to mammals.


1119-amino acid protein, from Latrodectus (mactans) tredecimguttatus spider venom glands.
Biological activity

In vertebrates, it binds with high affinity to presynaptic membranes. There, it stimulates neurotransmitter release from nerve endings and induces Ca2+ influx. It forms cation selective channels in bilayer and causes fusion of lipid membranes. The biological activity on nerve endings occurs at 10-10-10-9 M.

 Packaging and Prices

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8410 : unit price : free of charge
 Chemical and Physical Properties
Product code L8410  Molecular weight 130,000 Da
Product name LATROTOXIN (Alpha-)  Physical form
CAS No. Melting point
RTECS Solubility Aqueous buffers, pH range 6.5-8.5
UNIPROT Optical Activity
PubChem SID    
PubChem CID    
Purity >97 %    
Toxicity(LD50) IVN-MUS LD50: 45 μg/kg    
Chemical Name    
Storage & Reconstitution
Recommandations

It can be stored at 4 °C in presence of sodium azide up to 0.5 mg/ml during one month without any loss of activity or protein aggregation.
A small amount of the lyophilized product cannot be dissolved.
Repeating thawings and freezings causes a partial loss of activity.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8410 
Product name LATROTOXIN (Alpha-) 

- Krasnoperov et al., J. Natural Toxins (1992). 1:17
- Grasso, Biochem. Biophys. (1976) Acta 439:406
- Frontali et al., J. Cell Biol. (1976). 68:462
- Kiyatkin et al., FEBS Letts. (1990). 270:127
- Valtorta et al., J. Cell Biol. (1988). 107:2717
- Meldolesi et al., PNAS, USA (1984). 81:620
- Tzeng et al., J. Neurochem. (1979). 33:263
- Petrenko et al., Nature (1991). 353:65
 Links
Product code L8410 
Product name LATROTOXIN (Alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
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