Product ID L9074 
Molecular formula C6H8ClN7O .HCl

It is an epithelial channel blocker, it also blocks voltage-gated Na+ channels. It has an anti-hypertensive action.

Pyrazinoylguanidine , synthetic
Biological activity

It is a potassium-sparing diuretic, ion transporters, enzymes and receptors inhibitor. 10-6 M reversibly inhibit Na+ transport in Na+ channels of the high resistance apical plasma epithelial membrane, when added to the solution bathing this membrane. It has no effect on Na+ transport in basolateral plasma membrane [3-4]. The Na+ channel is the only ion transporter inhibited by Amiloride with an IC50 of less than 1 μM. IC50 in urinary epithelia = 0.34 μM, evaluated by the method of Cuthbert et al. 1978 [1].
it is a weak reversible inhibitor of Na+/Ca2+ exchanger.
IC50 = 2 mM for Na+-coupled solute transport in brush border membrane vesicles from rabbit kidney cortex and in LLC-PK1/CL4 cells [5].

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
10 g 120.00

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50 g 480.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9074 : unit price : free of charge
 Chemical and Physical Properties
Product code L9074  Molecular weight 266.1 g/mol
Product name AMILORIDE HCl  Physical form Light yellow solid
CAS No. 2016-88-8 Melting point 288-293 °C
RTECS UQ2275500 Solubility Well in water and ethanol
UNIPROT Optical Activity No optical activity
PubChem SID    
PubChem CID 16230    
Purity ≥ 98 % (TLC)    
Toxicity(LD50) mice (p.o.): 56 mg/kg
rat (p.o.): 36-85 mg/kg (depending on strain)
Chemical Name 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride.    
Storage & Reconstitution

Stable in dry state, store at room temperature.

Savety Recommandations


For research use only — not intended for food, diagnostic or therapeutic use

 Bibliographic References
Product code L9074 
Product name AMILORIDE HCl 

- Kleyman T.R. et al., "Amiloride and its analogs as tools in the study of ion transport." J. Membr. Biol. (1988). 105:1-21
- Garritsen A. et al., "Interaction of Amiloride and its analogs with Adenosine A1 receptors in calf bain", Biochem Pharmacol. (1990). 40(4):827
- Bently P.J., J. Physiol. (London) (1968). 195:317-330
- Sariban-Sohraby S. et al., Am. J. Physiol. (1986). 250:C175-C190
- Harris R.C. et al., Kidney Int. (1985). 27:310
Product code L9074 
Product name AMILORIDE HCl 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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