(Syn. : Amipramizide, Amipramidin, Guanamprazine)
AMILORIDE HCl | Product ID | L9074 |
| Name | AMILORIDE HCl |
| Molecular formula | C6H8ClN7O .HCl |
| Description |
It is an epithelial channel blocker, it also blocks voltage-gated Na+ channels. It has an anti-hypertensive action. Pyrazinoylguanidine , synthetic |
| Biological activity | It is a potassium-sparing diuretic, ion transporters, enzymes and receptors inhibitor. 10-6 M reversibly inhibit Na+ transport in Na+ channels of the high resistance apical plasma epithelial membrane, when added to the solution bathing this membrane. It has no effect on Na+ transport in basolateral plasma membrane [3-4]. The Na+ channel is the only ion transporter inhibited by Amiloride with an IC50 of less than 1 μM. IC50 in urinary epithelia = 0.34 μM, evaluated by the method of Cuthbert et al. 1978 [1]. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 10 g | 120.00 | ||
| 50 g | 480.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L9074 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L9074 | Molecular weight | 266.1 g/mol |
| Product name | AMILORIDE HCl | Physical form | Light yellow solid |
| CAS No. | 2016-88-8 | Melting point | 288-293 °C |
| RTECS | UQ2275500 | Solubility | Well in water and ethanol |
| UNIPROT | Optical Activity | No optical activity | |
| PubChem SID | |||
| PubChem CID | 16230 | ||
| Purity | ≥ 98 % (TLC) | ||
| Toxicity(LD50) | mice (p.o.): 56 mg/kg rat (p.o.): 36-85 mg/kg (depending on strain) |
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| Chemical Name | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride. | ||
| Storage & Reconstitution Recommandations |
Stable in dry state, store at room temperature. |
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| Savety Recommandations | Toxic For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L9074 |
| Product name | AMILORIDE HCl |
- Kleyman T.R. et al., "Amiloride and its analogs as tools in the study of ion transport." J. Membr. Biol. (1988). 105:1-21
- Garritsen A. et al., "Interaction of Amiloride and its analogs with Adenosine A1 receptors in calf bain", Biochem Pharmacol. (1990). 40(4):827
- Bently P.J., J. Physiol. (London) (1968). 195:317-330
- Sariban-Sohraby S. et al., Am. J. Physiol. (1986). 250:C175-C190
- Harris R.C. et al., Kidney Int. (1985). 27:310
Links
| Product code | L9074 |
| Product name | AMILORIDE HCl |
| External Links |
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