It is an antagonist of glutamate receptors by blocking glutamate-activated postsynaptic ion channels.

It has a reversible postsynaptic blocking effect: 50% decrease of excitatory postsynaptic current (EPSC) amplitude, at 4.4 x 10^-7 M concentration in insect neuro-muscular preparations and 1.6 x 10^-5 M in frog preparations.
In isolated frog spinal cord preparations, it inhibits glutamate-induced depolarizations of motoneurons, while having no effect on aspartate-induced responses.
Argiotoxin 636 reduces excitatory potentials at insect synapses that are thought to be mediated by non-NMDA receptors.
Argiotoxin 636 appears to act as an open-channel blocker of the NMDA-activated ion channel in mammalian neurons.

This product, shipped in dry state and under neutral gas, is stable during one year at 4 °C.

Stock solutions should be prepared with oxygen-free buffer and kept under neutral gas or vacuum. They are then stable for one month at 4 °C.

For research use only — not intended for food, diagnostic or therapeutic use