ARGIOTOXIN 636
Product ID L8401 
Name ARGIOTOXIN 636 
Molecular formula C29H52O6N10
Description

It is an antagonist of glutamate receptors by blocking glutamate-activated postsynaptic ion channels.


Polyamine , from Argiope lobata spider venom
Biological activity

It has a reversible postsynaptic blocking effect: 50% decrease of excitatory postsynaptic current (EPSC) amplitude, at 4.4 x 10-7 M concentration in insect neuro-muscular preparations and 1.6 x 10-5 M in frog preparations.
In isolated frog spinal cord preparations, it inhibits glutamate-induced depolarizations of motoneurons, while having no effect on aspartate-induced responses.
Argiotoxin 636 reduces excitatory potentials at insect synapses that are thought to be mediated by non-NMDA receptors.
Argiotoxin 636 appears to act as an open-channel blocker of the NMDA-activated ion channel in mammalian neurons.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 50ug 118.00

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5 x 50ug 472.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8401 : unit price : free of charge
 Chemical and Physical Properties
Product code L8401  Molecular weight 636.79 g/mol
Product name ARGIOTOXIN 636  Physical form
CAS No. 108687-79-2 Melting point
RTECS Solubility Well in water, saline, methanol and ethanol.
UNIPROT Optical Activity No optical activity
PubChem SID    
PubChem CID 122294    
Purity > 95 % (HPLC)    
Toxicity(LD50)    
Chemical Name (2S)-N-[5-[3-[3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propylamino]propylamino]pentyl]-2-[[2-(2,4-dihydroxyphenyl)acetyl]amino]butanediamide    
Storage & Reconstitution
Recommandations

This product, shipped in dry state and under neutral gas, is stable during one year at 4 °C.

Stock solutions should be prepared with oxygen-free buffer and kept under neutral gas or vacuum. They are then stable for one month at 4 °C.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8401 
Product name ARGIOTOXIN 636 

- Jackson et al., "Spider toxins as tools for dissecting elements of excitatory transmission." TINS (1988). 11(6):278-283
- Magazanik et al., "Argiopin - a naturally occuring blocker of glutamate-sensitive synaptic channels." Receptors and Ion Channels. de Gruyter. Berlin. (1987). 305-312
- Antonov et al., Neuroscience Letters, (1987). 83:179-184
- Lodge et al., "Non-competitive excitatory amino acid receptor antagonists." TIPS (1990). 11:81-86
- Priestley et al., "Antagonism of responses to excitatory amino acids on rat cortical neurons by the spider toxin, Argiotoxin 636." Br. J. Pharmacol. (1989). 97:1315-1323
 Links
Product code L8401 
Product name ARGIOTOXIN 636 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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