BENZOYLHETERATISINE HCl
Product ID L6085 
Name BENZOYLHETERATISINE HCl 
Molecular formula C29H37NO6.HCl
Description

It is a Na+ channel blocker a potent antiarrhythmic and a local anesthetic.


C19-diterpenoid alkaloid , from plants of the Ranunculaceae family.
Biological activity

It strongly antagonizes the effects of Aconitine. Its basic mechanism of action is the inhibition of Na+ conductivity of excitable cells. The Na+ channel blockage level does not depend on the potential and stimulus intensity. Its antiarrhythmic activity level is higher than that of Quinidine, and its mechanism of action significantly differs from that of other class I antiarrhythmics.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
10 mg 117.00

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50 mg 468.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6085 : unit price : free of charge
 Chemical and Physical Properties
Product code L6085  Molecular weight 532.07 g/mol
Product name BENZOYLHETERATISINE HCl  Physical form
CAS No. 1262758-10-0 Melting point 209-211 °C (decomp. alcohol)
RTECS Solubility Water
Moderately in methanol
Not well in ethanol
UNIPROT Optical Activity
PubChem SID    
PubChem CID 101703810    
Purity 97 % (TLC, mass spectrometry, NMR).    
Toxicity(LD50) IVN-RAT LD50: 5.0 mg/kg    
Chemical Name Heteratisan-14-one, 6-(benzoyloxy)-2-o-ethyl-8-hydroxy-1-methoxy-4-methyl-, (1-alpha,6-beta)-    
Storage & Reconstitution
Recommandations

For experiments on antiarrhythmic effects: 0.05 mg/kg to 0.5 mg/kg
For anesthetic activity on nerve terminals: 0.1% to 0.5% solution
For in vitro experiments: 10-9-10-8 M solution.
Store at +4°C, in dark place.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6085 
Product name BENZOYLHETERATISINE HCl 

- Aneja et al., "The diterpene alkaloids: the structure and stereochemistry of heteratisine." Tetrahedron (1973). 29 (21):3297-3308
 Links
Product code L6085 
Product name BENZOYLHETERATISINE HCl 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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