Product ID L6051 
Molecular formula C22H25NO6

It is a tubulin polymerisation inhibitor, a potent antimitotic, an anti-inflammatory agent and an antifibrogenic.

Alkaloid, from the plant Colchicum speciosum, Liliaceae.
Biological activity

It has an antimitotic activity: it binds to one tubulin end and prevents its polymerisation, it causes disappearence of the mitotic spindle and blocks the cell in mitosis.
It has an anti-inflammatory activity: It inhibits IL-1 production by peripheral blood monocytes, the release of growth factors by Kupffer cells and macrophages and the chemotactic migration of inflammatory cells into the liver.
It has an antifibrogenic activity: It inhibits microtubule assembly and thus prevent the transport and secretion of collagene, it induces collagenase activity.
It has activities on liver functions: It modifies membrane fluidity, it increases membrane enzymes acivities and glycogen levels.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
50 mg 77.50

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250 mg 310.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6051 : unit price : free of charge
 Chemical and Physical Properties
Product code L6051  Molecular weight 399.44 g/mol
Product name COLCHICINE  Physical form white to yellowish crystal powder
CAS No. 64-86-8 Melting point 153-155 °C
RTECS GH0700000 Solubility In alcohol, acetone and chloroform
Slightly in water
Not in ether
UNIPROT Optical Activity [alpha]D - 120° (c = 1.0 in chloroform).
PubChem SID    
PubChem CID 6167    
Purity 97 % (melting point, NMR, TLC).    
Toxicity(LD50) (LD50) rat (i.v.; s.c.; i.m.): 2.0 ± 0.3 mg/kg
(LD100) mice (i.v.; s.c.; i.m.): 5 mg/kg
Chemical Name N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide]    
Storage & Reconstitution

store at +4°C, in a dark place.

Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 Bibliographic References
Product code L6051 
Product name COLCHICINE 

- Rojkind, Pharmacology & Therapeutics (1992). 53(1)
- Andreu J.M. et al., Proc. Nat. Acad. Sci. USA (1982). 79:6756
- Salmon E.D. et al., J. Cell. Biol. (1984). 99:106
Product code L6051 
Product name COLCHICINE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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