DENDROTOXIN I
Product ID L8113-50UG 
Name DENDROTOXIN I 
Molecular formula
Description

It is a potent blocker of voltage-sensitive K+ channels. It can also block the Ca2+-activated K+ channels and it induces GABA release in synaptosomes.


60-amino acid polypeptide, with 3 disulfide bridges , from Dendroaspis polylepis polylepis snake venom.
Biological activity

It is a potent inhibitor of various types of voltage-sensitive K+ channels. It inhibits the K+ channels at the pre and post-synaptic level in the intestinal smooth muscle. It also inhibits Ca2+-sensitive K+ channels from rat skeletal muscle, incorporated into planar bilayers (Kd = 90 nM in 50 mM KCl). DTX-I would not affect the Ca2+ or voltage dependence of gating.
Like beta-BuTX, it affects neurotransmission at the neuromuscular junction by an interaction with pre-synaptic nerve terminals. As a consequence it is a potent convulsant when administered intracerebro-ventricularly.
nM ranges induce GABA release from brain synaptosomes.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 90.00

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5 Unité(s) 360.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8113-50UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8113-50UG  Molecular weight 7218 Da
Product name DENDROTOXIN I  Physical form
CAS No. 107950-33-4 Melting point
RTECS Solubility In water
UNIPROT P00979 Optical Activity
PubChem SID    
PubChem CID    
Purity > 97 % (HPLC)    
Toxicity(LD50) IPR-MUS LD50: > 4 mg/kg
ICE-MUS LD50: 8 μg/kg
   
Chemical Name    
Storage & Reconstitution
Recommandations

Store in saline


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8113-50UG 
Product name DENDROTOXIN I 

- Schweitz et al., "Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom." Toxicon (1990). 28(7):847-856
- Rehm et al., "Existence of different populations of the DTXi binding protein associated with neuronal K+ channels." Biochem. and Biophys. Res. Com. (1988). 153(1): 231-240
- Lucchesi et al., "Subconductance behavior in a maxi Ca2+-activated K+ channel induced by Dendrotoxin-I." Neuron, vol. 4, January, 1990.
 Links
Product code L8113-50UG 
Product name DENDROTOXIN I 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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