FERUTININE
Product ID L6006 
Name FERUTININE 
Molecular formula C22H30O4 (Ferutinine)
Description

It has estrogenic activity and is half agonist of estradiol receptors.


Complex esters of phenolcarbon acids, , from plants of the Ferula genus, Umbelliferae.
Biological activity

Ferutinine has a comparable type and level of activity with Diethylstilbestrol.
The specific estrogen-receptors in the cytoplasmic fraction of the hypothalamic area possesses a high affinity with estradiol and Ferutinine. Their association constant is respectively 3.4 x 108.M-1 and 2.0 x 108.M-1; in the cytosol of the mediobasal hypothalamus, it is 3.8 x 108.M-1 and 1.4 x 108.M-1.
It is clearly indicated that Ferutinine may exert its estrogenic effect through the regulatory centres of hypothalamus.
Experiments have estabished that cytosolic estrogen-receptors from human decidua interacts with Ferutinine with a low affinity: 1.58 % affinity. This low level is characteristic of a class of estrogen-like products.
It has also been established that Ferutinine increases the secretion rate of luteinizing hormone in male rats, parallel to the activation of the gonadotropin synthesis in the adenohypophysis.
Ferutinine
does not seem to have carcinogenic nor teratogenic properties. Administering of Ferutinine during 6 months at 0.1, 1 and 10 mg/kg does not provoke marked modifications in the internal organs nor in the peripheric blood.
In the first days of pregnancy, administration of Ferutinine at 10 to 100 mg/kg to rats leads to embryotoxic effects.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
10 mg 220.00

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50 mg 880.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6006 : unit price : free of charge
 Chemical and Physical Properties
Product code L6006  Molecular weight 358.46 g/mol
Product name FERUTININE  Physical form White powder
CAS No. 41743-44-6 Melting point
RTECS Solubility In chloroform
Slightly in 95 % alcohol
Not in water
UNIPROT Optical Activity
PubChem SID    
PubChem CID 389018    
Purity Ferutinine: 96 % (HPLC)    
Toxicity(LD50) ORL-MUS LD50: 2 225 mg/kg
ORL-RAT LD50: 4 700 mg/kg
   
Chemical Name [(3S,8aR)-3-hydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxybenzoate    
Storage & Reconstitution
Recommandations

Store at +4°C, in dark place


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6006 
Product name FERUTININE 

- Saidkhodjaev et al., "Ferutinine structure." Chem. Nat. Comp. (1973). 1:28-30
- Ahmedhodjaieva et al., "Influence of Ferutinine (Tefestrol) on the secretion of luteinizing hormone by hypophysis." Journ. Pharmacol. Toxicol. Moscow (1990) (Russian). 4:37-38
 Links
Product code L6006 
Product name FERUTININE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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