L8203-10UG - IMPERATOXIN-INHIBITOR
(Syn. : Ip Txi, Phospholipase A2 imperatoxin-1)
(Syn. : Ip Txi, Phospholipase A2 imperatoxin-1)
IMPERATOXIN-INHIBITOR | Product ID | L8203-10UG |
| Name | IMPERATOXIN-INHIBITOR |
| Molecular formula | IpTx1 large subunit: C491H735N137O161S13 IpTx1 small subunit: C120H177N31O43S |
| Description |
It is an inhibitor of Ca2+-release channels from sarcoplasmic reticulum. Heterodimer composed of a large subunit (104 AA) and a small subunit (27 AA) linked by disulfide bridge , from Pandinus imperator scorpion venom. |
| Biological activity | The toxin inhibits, with an apparent K in the nM range, ryanodine binding to the receptor both in cardiac and skeletal muscle, and it inhibits Ca2+ release from skeletal SR vesicles in the presence of micromolar extravesicular [Ca2+]. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 135.00 | ||
| 5 Unité(s) | 540.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8203-10UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8203-10UG | Molecular weight | 10 KDa |
| Product name | IMPERATOXIN-INHIBITOR | Physical form | |
| CAS No. | Melting point | ||
| RTECS | Solubility | In water and non-polar solvents (methanol, acetonitrile) | |
| UNIPROT | P59888 | Optical Activity | |
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| Purity | ââ°Â¥ 90 % (SDS-PAGE and HPLC) | ||
| Toxicity(LD50) | |||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Resuspend in buffer at pH 5 - 7. |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8203-10UG |
| Product name | IMPERATOXIN-INHIBITOR |
- Valdivia et al., "Sorpion toxins targeted against the sarcoplasmic reticulum Ca2+- release channel of skeletal and cardiac muscle." Proc. Nat. Acad. Sci. USA. (1992) 89:12185-12189
Links
| Product code | L8203-10UG |
| Product name | IMPERATOXIN-INHIBITOR |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
