ELAPITOXIN-Ls2a (Alpha-)
Product ID L8112 
Name ELAPITOXIN-Ls2a (Alpha-) 
Molecular formula
Description

It is an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b


66-amino acid peptide with 5 disulfide bridges , from Laticauda semifasciata snake venom
Biological activity

It is a nicotinic receptor antagonist, with a reversible binding to the receptor (its affinity is 1/40th that of Erabutoxin b).
Its binding to the acetylcholine receptors of Torpedo marmorata electric organs:
Kd = 1.6 x 10-9 M.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 1mg 144.00

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5 x 1mg 576.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8112 : unit price : free of charge
 Chemical and Physical Properties
Product code L8112  Molecular weight 7,229 Da
Product name ELAPITOXIN-Ls2a (Alpha-)  Physical form
CAS No. 75433-28-2 Melting point
RTECS Solubility In water and saline
UNIPROT P01379 Optical Activity
PubChem SID    
PubChem CID    
Purity > 90 %. Salt-free, freeze-dried preparation
Homogeneous (CM-cellulose & gel-chromatography)
   
Toxicity(LD50) IMU-MUS LD50: 0.85 mg/kg    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable in freeze-dried state. Keep in dark and cold place.
In solution, keep at -20 °C.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8112 
Product name ELAPITOXIN-Ls2a (Alpha-) 

- Tamiya et al., "Studies on sea-snake venoms: crystallization of Erabutoxins a and b from Laticauda semifasciata venom." Biochem. J. (1966). 99:624-630
- Ishikawa et al., "Structures of snake toxins and their affinity to the acetylcholine receptor of fish electric organ." Toxicon (1977). 15:477-488
- Chiappinelli et al., "The effects of a- and b- neurotoxins from the venoms of various snakes on transmission in autonomic ganglia." Brain Res. (1981). 211:107-126
- Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451
 Links
Product code L8112 
Product name ELAPITOXIN-Ls2a (Alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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