Lqh alpha IT (Recombinant)
Product ID L8222 
Name Lqh alpha IT (Recombinant) 
Molecular formula
Description

It is a scorpion alpha-insect toxin, which prolongs the evoked action potential by an inhibition of sodium current inactivation in insects and mammals. Lqh alpha- IT serves as a marker for receptor site-3 on insect and mammalian sodium channels.


66-amino acid polypeptide with 4 disulfide bridges produced in E.coli (1,2), originally from Leiurus quinquestriatus hebraeus scorpion venom
Biological activity

Lqh alpha- IT is highly toxic to insects.
It also has a strong toxicity to mice by subcutaneous injection (but very weak by intraventricular route).
Lqh alpha- IT causes an extreme prolongation of the action potential in both cockroach giant axon and rat skeletal muscle preparations as a result of the slowing and incomplete inactivation of the sodium currents.
Lqh alpha- IT is very active on insect and skeletal muscle sodium channels expressed in Xenopus oocytes but is very weak on rat brain IIa channels.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 50ug 118.00

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5 x 50ug 472.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8222 : unit price : free of charge
 Chemical and Physical Properties
Product code L8222  Molecular weight 7380.4 Da
Product name Lqh alpha IT (Recombinant)  Physical form
CAS No. Melting point
RTECS Solubility Well in water and saline.
UNIPROT P17728 Optical Activity
PubChem SID    
PubChem CID    
Purity > 96%    
Toxicity(LD50) blowfly larvae: delayed sustained contraction paralysis (PU50): 140 ng/g
isopods (terrestrial crustaceans): paralysis within 5 mn (PU50): 200 ng/g
mice: lethality observed after 24 h (LD50): 5 μg/kg
   
Chemical Name    
Storage & Reconstitution
Recommandations

Store at 4°C


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8222 
Product name Lqh alpha IT (Recombinant) 

- Tugarinov et al., (1997) Biochemistry 36,2414-2424. 2.
- Zilberberg et al., (1997) J. Biol. Chem. 272, 14810-14818.
- Eitan et al., Biochemistry (1990). 29:5941-5947
- Gordon et al., J. Biol. Chem. (1996) 271:8034-8045
- Karbat et al., (2004) J, Biol. Chem. 279, 31679-31686.
- Gilles et al., (2000) Eur. J. Neurosci. 12, 2823-2832
 Links
Product code L8222 
Product name Lqh alpha IT (Recombinant) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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