It is a scorpion alpha-insect toxin, which prolongs the evoked action potential by an inhibition of sodium current inactivation in insects and mammals. Lqh alpha- IT serves as a marker for receptor site-3 on insect and mammalian sodium channels.

Lqh alpha- IT is highly toxic to insects.
It also has a strong toxicity to mice by subcutaneous injection (but very weak by intraventricular route).
Lqh alpha- IT causes an extreme prolongation of the action potential in both cockroach giant axon and rat skeletal muscle preparations as a result of the slowing and incomplete inactivation of the sodium currents.
Lqh alpha- IT is very active on insect and skeletal muscle sodium channels expressed in Xenopus oocytes but is very weak on rat brain IIa channels.

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