MELITTIN
Product ID L8403 
Name MELITTIN 
Molecular formula C131H229N39O31
Description

It is an inhibitor of protein-kinases and cell membrane lytic factor from the venom of the Honeybee, Apis mellifera.

The NH2 terminal part of the molecule is predominantly hydrophobic and the C terminal part is hydrophilic and strongly basic.


26-amino acid peptide with no disulfide bridge , from Apis mellifera bee venom
Biological activity

It is an inhibitor of
- protein kinase C,
- Ca2+/calmodulin-dependent protein kinase II,
- myosin light chain kinase
- and Na+/K+-ATPase (synaptosomal membrane),
with an IC50 of 1-4 µM.
It is also a cell membrane lytic factor.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 1mg 49.00

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5 x 1mg 196.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8403 : unit price : free of charge
 Chemical and Physical Properties
Product code L8403  Molecular weight 2846.46 Da
Product name MELITTIN  Physical form Powder
CAS No. 20449-79-0 Melting point
RTECS OS3965000 Solubility Well in water and saline
UNIPROT P01501 Optical Activity
PubChem SID    
PubChem CID 16133648    
Purity    
Toxicity(LD50) IPR-MUS LD50: 17.7 to 7.4 mg/kg
IVN-MUS LD50: 7.04 mg/kg
IVN-RAT LD50: 1.4 mg/kg
IPR-GPG LD50: 2.75 mg/kg
   
Chemical Name    
Storage & Reconstitution
Recommandations

Store preferably at -20 °C;

Solution for use: 100 μM. It can be then freezed and thawed.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8403 
Product name MELITTIN 

- Raynor et al., "Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin." J. Biol. Chem. 1991 266(5):2753-2758
- Schweitz, "Lethal potency in mice of toxins from scorpion, sea anemone, snake and bee venoms following intraperitoneal and intracisternal injection." Toxicon (1984). 22:308-311
- Habermann, "Bee and wasp venoms: the biochemistry and pharmacology of their peptides and enzymes are reviewed." Science (1972). 177:314-322
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