NICARDIPINE HCl
Product ID L9069 
Name NICARDIPINE HCl 
Molecular formula C26H29N3O6.HCl
Description

a L-type Ca2+ channels blocker; antihypertensive.


Dihydropyridine derivative, , synthetic.
Biological activity

Inhibits L-type Ca2+ channels in chick sensory neurons [4].
Antianginal; antihypertensive.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 230.00

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100 mg 920.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9069 : unit price : free of charge
 Chemical and Physical Properties
Product code L9069  Molecular weight 515.99 Da.
Product name NICARDIPINE HCl  Physical form light yellow solid.
CAS No. 54527-84-3 Melting point 168-170 °C.
RTECS Solubility in dilute aqueous alkaline solution and chloroform-methanol (1:1); not in water.
UNIPROT Optical Activity
PubChem SID    
PubChem CID 41114    
Purity min. 99%. (TLC)    
Toxicity(LD50) rat (orally): 187 mg/kg; rat (i.v.): 15.5 mg/kg;
mice (orally): 322 mg/kg; mice (i.v.): 19.9 mg/kg.
rat (i.p.): 155 mg/kg; rat (s.c.): 683 mg/kg;
mice (i.p.): 123 mg/kg; mice (s.c.): 540 mg/kg.
   
Chemical Name 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2- [methyl-(phenylmethyl)amino]ethyl ester hydrochloride.    
Storage & Reconstitution
Recommandations

stable when kept dry; store at room temperature in a dark place.


 
Savety Recommandations

do not inhale nor swallow, prevent contact with skin.

 
 Bibliographic References
Product code L9069 
Product name NICARDIPINE HCl 

- Triggle et al., TiPS (1989). 10:507-511
- Sato et al., "Mechanism of Mesaconitine-induced contractile response in guinea-pig ileum." J. Pharm. Pharmacol. (1980). 7:249
- Chang et al., Can. J. Physiol. Pharmacol. (1989). 67:1493
- Aosaki et al., "Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons." Pflgers Arch. (1989). 414:150-156
 Links
Product code L9069 
Product name NICARDIPINE HCl 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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