NIFEDIPINE
Product ID L9070 
Name NIFEDIPINE 
Molecular formula C17H18N2O6
Description

a L-type Ca2+ channels blocker; antihypertensive.


Dihydropyridine derivative, , synthetic.
Biological activity

Inhibits L-type Ca2+ channels in chick sensory neurons [4].
Antihypertensive; vasodilator; antianginal.
Has teratogenic effect on some animal species

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 760.00

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100 mg 3 040.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9070 : unit price : free of charge
 Chemical and Physical Properties
Product code L9070  Molecular weight 346.33 Da.
Product name NIFEDIPINE  Physical form yellow crystals.
CAS No. 21829-25-4 Melting point 172-174 °C.
RTECS US7975000 Solubility freely in acetone, chloroform, DMSO; less in ethanol; not in water.
UNIPROT Optical Activity
PubChem SID    
PubChem CID 4485    
Purity min. 98%. (TLC)    
Toxicity(LD50) orally: rat: 1 022 mg/kg; mice: 310 mg/kg; cat: 100 mg/kg; rabbit: 504 mg/kg
i.v.: rat: 6 mg/kg; mice: 4.20 mg/kg; rabbit: 2 mg/kg
i.p.: rat: 230 mg/kg; mice: 185 mg/kg; cat: 190 mg/kg
s.c.: rat: > 10 mg/kg; mice: > 10 mg/kg
   
Chemical Name 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester.    
Storage & Reconstitution
Recommandations

Stable when kept dry; store at +4°C, in dark place. Caution: the solution is very light-sensitive.


 
Savety Recommandations

Do not inhale nor swallow; prevent contact from skin.

 
 Bibliographic References
Product code L9070 
Product name NIFEDIPINE 

- Triggle et al., TiPS (1989). 10:507-511
- Weiss et al., "The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity." Science (1990). 247:1474-1477
- Trabrizchi et al., "Benextramine and nifedipine distinguish between sub-classes of a1-adrenoreceptors." Life Sciences (1989). 45:2577
- Aosaki et al., "Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons." Pflgers Arch. (1989). 414:150-156
 Links
Product code L9070 
Product name NIFEDIPINE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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