CONOTOXIN MVII A (Omega-)
Product ID L8501 
Name CONOTOXIN MVII A (Omega-) 
Molecular formula C102H172N36O32S7
Description

It is a N-type Ca2+ channel blocker.


25-amino acid peptide with 3 disulfide bridges , synthetic, originally from Conus magus molluscan venom.
Biological activity

ω-CgTx MVIIvA blocks Cav2.2/CACNA1B calcium channels (IC50=180 nM). When injected in mammals, it induces adverse effects, such as tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion.

ω-Conotoxin MVIIvA (from Conus magus) and ω-Conotoxin GVI A (from Conus geographus) are both neuronal Cav2  channel blockers and appear to compete for the same sites in mammalian brain, but they seem to present some differences in their receptor binding characteristics; in particular the high affinity binding of MVII A has narrower specificity in amphibian brain.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 90.00

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5 x 100µg 360.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8501 : unit price : free of charge
 Chemical and Physical Properties
Product code L8501  Molecular weight 2,639.2 Da
Product name CONOTOXIN MVII A (Omega-)  Physical form
CAS No. 107452-89-1 Melting point
RTECS Solubility Well in water and saline
UNIPROT P05484 Optical Activity
PubChem SID    
PubChem CID 16135415    
Purity ~ 85 % (HPLC)    
Toxicity(LD50)    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable in freeze dried state.
In solution, keep at -20°C.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8501 
Product name CONOTOXIN MVII A (Omega-) 

- Olivera et al., "Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using Omega-conotoxin from Conus magus venom." Biochemistry. (1987) 26:2086-2090
 Links
Product code L8501 
Product name CONOTOXIN MVII A (Omega-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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