Product ID L9043 
Name PEMPIDINE Tartrate 
Molecular formula C10H21N .C4H6O6

a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Antihypertensive. Good penetration of biological membranes. Monocyclic analog of TEMECHINE.

Piperidine derivative, , synthetic.
Biological activity

For comparative information see the attached tables. Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.

Produces a slowly developing voltage-dependent block of ionoforetically activated cholinergic currents of the lobster gastric mill [3, 4].

CNS activity: see the attached table.

35 mg/kg increases ATP and decreases AMP [5]. Modulation of Dopamine release [6]. Increases IP level (Sherman).

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 86.00

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100 mg 344.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9043 : unit price : free of charge
 Chemical and Physical Properties
Product code L9043  Molecular weight 305.37 Da.
Product name PEMPIDINE Tartrate  Physical form colorless crystal powder
CAS No. 79-55-0 (base), 546-48-5 (tartrate), 6152-93-8 (tosilate). Melting point 150-151°C
RTECS Solubility water, ethanol.
UNIPROT Optical Activity
PubChem SID    
PubChem CID 120729    
Purity min. 98%.
TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.78, development with Dragendorff� reagent); NMR (D2O).
Toxicity(LD50) mice (orally): 275 mg/kg    
Chemical Name 1,2,2,6,6-pentamethylpiperidine d-tartrate.    
Storage & Reconstitution

store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 6.56 ml), stable for 1-2 days at 20°C.

Savety Recommandations

Do not swallow or inhale; avoid eye and skin contact.

 Bibliographic References
Product code L9043 
Product name PEMPIDINE Tartrate 

- Lee J.E. et al., Nature (1958) 181:1717
- Romano C. et al, Psychopharmacologie (1981) 74(4):310-315
- Mader et al., "Voltage dependent blocade of a crustacean muscle", J. Exp. Biol. (1980). 88:147-159
- Lingle, J. Physio. (1983) (London). 339:419-437
- Tichonenko V.M., Farm.Toxikol.(Kiev) (1980). (13):109-125 (1978); [p.42-44 Engl.]., CA 93: 762
- Rapier C. et al., Neuropharm. (1990). 54(3):937-945
- Spinks et al., Nature (1958). 181:1397
- Corne et al., Brit.J.Pharm. (1958). 13(5):501-520
- Spinks et al., Brit.J.Pharm. (1958). 13(4):501-520
Product code L9043 
Product name PEMPIDINE Tartrate 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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