L9038 - PENETRAN Cl
PENETRAN Cl | Product ID | L9038 |
| Name | PENETRAN Cl |
| Molecular formula | C14H14NOCl .HCl synthetic. |
| Description |
an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes; acetylcholine synthesis inhibitor; good penetration of biological membranes. Quinicludine derivative, |
| Biological activity | Cell permeable inhibitor of high-affinity choline uptake (HAChU). For comparative information see the attached table. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 20 mg | 690.00 | ||
| 100 mg | 2 760.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L9038 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L9038 | Molecular weight | 284.18 Da. |
| Product name | PENETRAN Cl | Physical form | slightly yellowish crystal powder. |
| CAS No. | Melting point | 185-187 °C. | |
| RTECS | Solubility | water, ethanol and DMSO. | |
| UNIPROT | Optical Activity | ||
| PubChem SID | |||
| PubChem CID | 4139735 | ||
| Purity | min. 99.5%. TLC [Silufol UV-254, MeOH:NH3(25%) Rf =0.68, development in UV light followed with Dragendorff� reagent]; NMR (D2O). |
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| Toxicity(LD50) | mice (orally) >700 mg/kg | ||
| Chemical Name | Z-2-((3'chlorophenyl)methylene]-3-quinuclidon HCl; Z-2-[(3'-chlorophenyl)methylene]-3-oxoquinuclidine HCl |
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| Storage & Reconstitution Recommandations |
Store in a dark place in a dessicator; solutions are stable for 1-2 days at room temperature. Solution for use: 10-3 M (2 mg in 8.06 ml). |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L9038 |
| Product name | PENETRAN Cl |
- Dahlbom R. et al., "Cell Mol. Basis Cholinergic Funct.", Dowdall M. J. and Hawthorne J. N. Eds., Horwood, Chichester U.K., (1987) 347-354
- Sterling et al., "Inhibition of high-affinity choline uptake and acetylcholine synthesis by quinuclidinyl and hemicholinium derivatives", J. Neurochem.(1986). 46(14):1170-1175
- Doukas P.H. et al., ibid, 355-360
- Baltzod F. et al., Biochem. Pharm. (1980). 29(18):2413-2416
- Tamaru M. et al., Brain Res (1988). 473(2):205-226
- Dowdall M.J. et al., in Cholinergic mechanisms and Psycopharmacology, Ed. D.J.Jenden, Plenum Press, N-Y, (1978). 359
Links
| Product code | L9038 |
| Product name | PENETRAN Cl |
| External Links |
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