a GABA-gated chloride channel blocker, non-competitive GABA antagonist in mammals.

(IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 0.5 nM;
inhibition of the GABA-dependent Cl- current at 1.09 nM;
(IC50) for [3H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 �M (Ticku M.);
(IC50) for [35S]-tert.butyl-thionebicyclophosphate binding with the human brain membranes: 1.1 �M (Casida J.);
experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Propybicyphat up to 10 �M.

store at room temperature