Product ID L9036 
Molecular formula C8H16INO

an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes; bicyclic inhibitor of Choline; acetylcholine synthesis inhibitor; weak penetration of biological membranes.

Quinicludine derivative, , synthetic.
Biological activity

Cell impermeable inhibitor of high-affinity choline uptake (HAChU). For comparative information see the attached table. Inhibits HAChU (1 �M of Choline) into Torpedo T-sacs: IC50 = 8 �M; Homocholine: IC50 = 2 �M; Thiocholine: IC50 = 6 �M; Acetylcholine: IC50 = 10 �M; TMA: IC50 = 63 �M; TEA: IC50 = 132 �M. In rat cortex synaptosomes: IC50 = 72.0 �M [2]; Hemicholium-3: IC50 = 0.06 �M; Acetylsecohemicholinium-3: IC50 = 0.64 �M.

40 % inhibition of ACh synthesis [2] (see comparative table).
poor penetration of biological membranes.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 530.00

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100 mg 2 120.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9036 : unit price : free of charge
 Chemical and Physical Properties
Product code L9036  Molecular weight 269.13 Da.
Product name QUIRESTOL  Physical form slightly yellowish crystal powder.
CAS No. 6659-52-5 Melting point >300 °C.
RTECS Solubility water, ethanol and DMSO.
UNIPROT Optical Activity
PubChem SID    
PubChem CID    
Purity min. 99.5%. (NMR (D2O))    
Toxicity(LD50) mice (orally) 400 mg/kg    
Chemical Name 1-methyl-3-hydroxyquinuclidinium iodide.    
Storage & Reconstitution

Store in a dark place in a dessicator; solutions are stable for 1-2 days at room temperature. Solution for use: 10-3M (2 mg in 7.43 ml).

Savety Recommandations  
 Bibliographic References
Product code L9036 
Product name QUIRESTOL 

- Dahlbom R. et al., "Cell Mol. Basis Cholinergic Funct.", Dowdall M. J. and Hawthorne J. N. Eds., Horwood, Chichester U.K., (1987) 347-354
- Sterling et al., "Inhibition of high-affinity choline uptake and acetylcholine synthesis by quinuclidinyl and hemicholinium derivatives", J. Neurochem.(1986). 46(14):1170-1175
- Doukas P.H. et al., ibid, 355-360
- Baltzod F. et al., Biochem. Pharm. (1980). 29(18):2413-2416
- Tamaru M. et al., Brain Res (1988). 473(2):205-226
- Dowdall M.J. et al., in Cholinergic mechanisms and Psycopharmacology, Ed. D.J.Jenden, Plenum Press, N-Y, (1978). 359
Product code L9036 
Product name QUIRESTOL 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
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