SCYLLATOXIN
Product ID L8202 
Name SCYLLATOXIN 
Molecular formula C142H243N45O39S7
Description

It is a blocker of Apamin-sensitive Ca2+-activated K+ channels.


31-amino acid peptide with 3 disulfide bridges. Synthetic, originally from Leiurus quinquestriatus Hebraeus scorpion venom
Biological activity

Scyllatoxin (Leiurotoxin I) completely inhibits Apamin binding to rat brain synaptosomal membranes (Ki = 75 pM). Like Apamin, Scyllatoxin blocks the epinephrine-induced relaxation of guinea pig teniae coli (ED50 = 6.5 nM). A series of analogs that allow the use of different labeling techniques have also been prepared: the [Tyr2] Scyllatoxin analog, allowing labelling by iodination, is available.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 120.00

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5 x 100µg 480.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8202 : unit price : free of charge
 Chemical and Physical Properties
Product code L8202  Molecular weight 3429.18 Da
Product name SCYLLATOXIN  Physical form
CAS No. 142948-19-4 Melting point
RTECS Solubility Well in water and saline
UNIPROT P16341 Optical Activity
PubChem SID    
PubChem CID 71311759    
Purity > 95%    
Toxicity(LD50)    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable in freeze-dried state.
In solution, keep at -20 °C.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8202 
Product name SCYLLATOXIN 

- Chicci et al., "Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom." J. Biol. Chem.,(1988). 263(21):10192-10197
- Auguste et al., "Leiurotoxin I (Scyllatoxin), a peptide ligand for Ca2+-activated K+ channels." J. Biol. Chem., (1990) 265(8):4753-4759
- Martins et al., FEBS Letters,(1990) 260(2):249-253
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