TEMPIDONE - Latoxan Valence France

TEMPIDONE

Product ID	L9046
Name	TEMPIDONE
Molecular formula	C₉H₁₇NO .HCl
Description	a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Sedative. Secondary analog of Pempidone. Antioxidant, radical scavenger. Piperidine derivative, , synthetic.
Biological activity	For comparative information see the attached tables. Cell permeant central nicotinic cholinoreceptor blocker without action on skeleton muscle innervation. Nicotinic AChR antagonist, autonomic ganglioblocker [1-3]. Hypotensive (purely anti-nicotinic) without smooth muscles relaxation - up to 80 ï¿½g/kg has no antagonism with BaCl2, conc. KCl, noradrenaline, histamine, 5-HT, angiotensin, bradyquinine [4]. Antioxydant [5]: precursor of stable TEMPO nitroxyl radical. Inhibits cell in metastase : COLCHICINE-like action [6]: Hepatoma 22 (C 3H mice) : 90-270: 35-50: 66-100 Erlich carcinoma (albino mice): 100-380: 40-85: 66-100 Brown-Pearce carcinoma (rabbits):15-150: remarkable reduction of metastases and primary tumor. Sedative, hypnotic [2].

Packaging and Prices

Packaging	Price (€)	Buy Now
20 mg	232.00	add to cart
100 mg	928.00	add to cart
For quotation of big quantities, please Contact us

Product Technical Documents

	Safety Data Sheet Available on request, please Contact us Ref. SDS_L9046 : unit price : free of charge

Chemical and Physical Properties

Product code	L9046	Molecular weight	191.70 Da.
Product name	TEMPIDONE	Physical form	colorless crystal powder.
CAS No.	33973-59-0 (base), 826-36-8 (HCl), 29334-13-2 (tosilate).	Melting point	195-196 °C.
RTECS		Solubility	water, ethanol.
UNIPROT		Optical Activity
PubChem SID
PubChem CID	94452
Purity	min. 99.5%. TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.41, development with Dragendorffï¿½ reagent); NMR (D2O).
Toxicity(LD50)	mice (orally): 200-230 mg/kg - mice (i.v.): 860-950 mg/kg; rats (i.v.): 600-700 mg/kg. - mice (i.p.): 350-400 mg/kg; rats (i.p.): 600-700 mg/kg - mice (i.m.): 500 mg/kg
Chemical Name	2,2,6,6-tetramethylpiperidone-4 hydrochloride.
Storage & Reconstitution Recommandations	store at room temperature. Solution for use: dissolve in water: 10-³M (2 mg in 10.43 ml), stable for 1-2 days at 20°C.
Savety Recommandations

Bibliographic References

Product code	L9046
Product name	TEMPIDONE

- Brehteric et al., Nature (1959). 184:1707-1709
- Chodera A. et al., Pharm. Zentralhalle (1964). 103(1):17-23
- Rojas R.L., Rev. Cubana Farm. (1979). 13:37-45 and 163-173
- Rojas R.L., Rev. Cubana Farm. (1979). 16:146-156
- Komarov P.G. et al., Dokl. Akad. Nauk SSSR (1987). 297(3):734-737
- Brito et al., Rev. Cubana Farm. (1982). 16(2):146-156

Links

Product code	L9046
Product name	TEMPIDONE
External Links	PubMed
	Biomedical Citations From PubMed
	Toxicology Citations From PubMed

	PubChem CID

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