TETRAETHYLAMMONIUM Chloride
Product ID L9073 
Name TETRAETHYLAMMONIUM Chloride 
Molecular formula C8H20ClN
Description

K+ channels blocker; cholinoreceptors antagonist; ganglioblocker.


, synthetic.
Biological activity

The exposure of rat tracheal segments to threshold/subthreshold concentrations of TEA produces remarkable Airway Hyperresponsiveness (AH) to cooling provocation [Chand N.].

K+ channel blockade is involved in the induction of non specific AH in this model [4]. At the concentration of 10 mM: EC50 = 3.4 �M (1.8 - 6.4).

1 mM blocks InsP3-induced Ca2+ release in microsomal fractions isolated from rat brain incubated in media containing 100 mM KCl. Decreases the InsP3-induced Ca2+ release by 80 � 5% [5].

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 36.00

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100 mg 144.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9073 : unit price : free of charge
 Chemical and Physical Properties
Product code L9073  Molecular weight 165.7 Da.
Product name TETRAETHYLAMMONIUM Chloride  Physical form white to light yellow solid.
CAS No. 56-34-8 Melting point
RTECS BS6125000 Solubility well in water, ethanol, chloroform and acetone.
UNIPROT Optical Activity
PubChem SID    
PubChem CID 5946    
Purity min. 98%.    
Toxicity(LD50) rat (orally): 2.63 g/kg; mice (orally): 833 mg/kg
rat (i.v.): 56 mg/kg; mice (i.v.): 37 mg/kg
mice (i.p.): 65 mg/kg; rat (s.c.): 200 mg/kg
   
Chemical Name Tetraethylammonium chloride.    
Storage & Reconstitution
Recommandations

store at room temperature in dessicator; solutions are stable to heating.


 
Savety Recommandations  
 Bibliographic References
Product code L9073 
Product name TETRAETHYLAMMONIUM Chloride 

- Barlow, Molec. Pharm. (1971). 7:357-366
- Kellet Jr., J. Pharm. Sci. (1965). 54(3):883-887
- Eldefrawi M.E. et al., "Permeability of the abdominal nerve cord of the american cockroach, Periplaneta americana L. to quaternary ammonium salts." J. Exp. Biol. (1967). 46:1-12
- Chand N. et al., "Potassium channel blockade induces nonspecific airway hyperractivity in rat isolated trachea: pharmacologic modulation." Pharm. Comm. (1994). 4(3):173-179
- Shah J. et al., "Potassium-channel blockers inhibit inositol triphosphate-induced calcium release in the microsomal fractions isolated from the rat brain." Biochem. J. (1988). 250:617-620
 Links
Product code L9073 
Product name TETRAETHYLAMMONIUM Chloride 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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