TETRAZOLINE HCl | Product ID | L6217 |
| Name | TETRAZOLINE HCl |
| Molecular formula | C12H14N2.HCl |
| Description |
It is a cholinesterase and monoamine oxidase (MAO) inhibitor and a weak muscarinic receptors antagonist. Quinazoline alkaloid , synthetic. |
| Biological activity | In vitro: IC50 = 9.7x10-7 g/ml for cholinesterase activity. In vivo: LD50 (i.p. mice) dose blocks 52 % of cholinesterase activity. In isolated small intestine section, 10-6 g/ml and 10-5 g/ml moderately increase the contractions caused by ACh. On the contrary, contractions are inhibited by 10-4 g/ml. In consequence, Tetrazoline HCl is a blocker of muscarinic cholinoreceptors located in isolated small intestine section. This explains its muscle relaxant effect. 100-130 mg/kg (i.p.) in mice cause breathing disruption then death by asphyxia. It has no significant effect on cholinoreceptors of the C.N.S. It does not prolong the quiver caused by arecholine, but doubles this caused by nicotine. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 20 mg | 102.00 | ||
| 100 mg | 408.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6217 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6217 | Molecular weight | 222.5 g/mol |
| Product name | TETRAZOLINE HCl | Physical form | White crystal powder |
| CAS No. | Melting point | 154-155 °C | |
| RTECS | Solubility | In water and ethanol Practically not in chloroform and benzene |
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| UNIPROT | Optical Activity | No optical activity | |
| PubChem SID | 114518316 | ||
| PubChem CID | 6420075 | ||
| Purity | > 98% | ||
| Toxicity(LD50) | IVN-MUS LD50: 45.4 mg/kg IPR-MUS LD50: 121.4 mg/kg |
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| Chemical Name | 6,7,8,9-tetrahydro-11H-pyrido[2,1-b]- quinazoline hydrochloride | ||
| Storage & Reconstitution Recommandations |
Store at +4°C, in dark place. |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L6217 |
| Product name | TETRAZOLINE HCl |
- Fitzgerald et al., "6, 7, 8, 9-tetrahydropyrido-quinazoline, a new class of alkaloids from Mackinlava species (Araliaceae)" Aust. J. Chem. (1966). 19(1):151-159
- Spath et al., "Uber Derivate des Peganins und ihre Ring-Homologen" J. Mitt. Uber Peganin, Chem. Ber. 6 (1935). (68):2221-2226
- Jen et al., "A new class of antihypertensive agents, 1, 2, 3, 5-Tetrahydroimidazo [2,1-b] quinazoline." J. Med. Chem.1 (1972). 15(7):727-731
- Tuliaganov, Higher Doctoral thesis of Medecine, Moscow (1981) (Russian). Confidential.
Links
| Product code | L6217 |
| Product name | TETRAZOLINE HCl |
| External Links |
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