L6218 - MACKINAZOLINONE HCl
MACKINAZOLINONE HCl | Product ID | L6218 |
| Name | MACKINAZOLINONE HCl |
| Molecular formula | C12H12N2O.HCl |
| Description |
It inhibits cholinesterase activity in vitro. In vivo, high doses induce sleep and enhance the effect of soporifics. Quinazolone alkaloid , synthetic. |
| Biological activity | High dose inhibits orientation reaction and motor functions. So, it induces somnolence, even sleep. Half and quarter LD50 doses (= moderate doses) enhance the effect of soporifics. In vitro, it causes weak inhibition of cholinesterase acitivity with IC50 = 6.2x10-4 g/ml, and of monoaminoxidase at 10-4 M reduces by 18.8 % its activity. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 20 mg | 106.00 | ||
| 100 mg | 424.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6218 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6218 | Molecular weight | 236.5 g/mol |
| Product name | MACKINAZOLINONE HCl | Physical form | White crystal powder |
| CAS No. | 2446-62-0 (parent) | Melting point | 269-271 °C |
| RTECS | Solubility | In ethanol and water Not well in chloroform and acetone |
|
| UNIPROT | Optical Activity | ||
| PubChem SID | |||
| PubChem CID | 523975 | ||
| Purity | ⥠99% TLC [silufol, benzene:acetone (2:1)], mass spectrometry, melting point | ||
| Toxicity(LD50) | mice (i.v.) : 170 mg/kg, (i.p.) : 504 mg/kg | ||
| Chemical Name | 6,7,8,9-Tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one hydrochloride | ||
| Storage & Reconstitution Recommandations |
Stable in freeze-dried state Store at +4°C, in dark place. |
||
| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
||
Bibliographic References
| Product code | L6218 |
| Product name | MACKINAZOLINONE HCl |
- Fitzgerald et al., "6, 7, 8, 9-tetrahydropyrido-quinazoline, a new class of alkaloids from Mackinlava species (Araliaceae)" Aust. J. Chem. (1966). 19(1):151-159
- Spath et al., "Uber Derivate des Peganins und ihre Ring-Homologen" J. Mitt. Uber Peganin, Chem. Ber. 6 (1935). 68:2221-2226
- Jen et al., "A new class of antihypertensive agents, 1, 2, 3, 5-Tetrahydroimidazo [2,1-b] quinazoline." J. Med. Chem.1 (1972). 15(7):727-731
- Touliaganov, Ph. D. Thesis, Moscow (1981) (Russian).
Links
| Product code | L6218 |
| Product name | MACKINAZOLINONE HCl |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
|
PubChem CID
|
|
