CVFm (Cobra Venom Factor)
Product ID L8117-100UG 
Name CVFm (Cobra Venom Factor) 
Molecular formula Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits
Description

It is a non-toxic, complement-activating component of cobra venom.

Purified from Naja melanoleuca venom, a non-CITES Naja species.


Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits with molecular masses respectively of about 70, 50, and 30 kDa, the two large subunits being glycosylated. From Naja melanoleuca venom.
Biological activity

It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.

 

 Field of useIt is used for immuno-suppression, decomplementing blood in vivo & in vitro, its dosage for mice is about 1µg per gram of body weight.

 

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 125.00

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5 Unité(s) 500.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8117-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8117-100UG  Molecular weight ~ 150 kDa
Product name CVFm (Cobra Venom Factor)  Physical form Lyophilized
CAS No. 308067-24-5 Melting point
RTECS Solubility PBS pH 7.2, DMSO 10%
UNIPROT Q91132 Optical Activity
PubChem SID    
PubChem CID    
Purity > 95% (HPLC)    
Toxicity(LD50)    
Chemical Name    
Storage & Reconstitution
Recommandations

Shipped at ambient temperature under lyophilized powder. In solution, store at -20°C (-4°F). Do not freeze-thaw.

Aliquot sample if required and store at -80°C (-112°F).

 


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 

 
 Bibliographic References
Product code L8117-100UG 
Product name CVFm (Cobra Venom Factor) 

- Toxicon. 2005 Sep 15;46(4):394-403. "Naja melanoleuca cobra venom contains two forms of complement-depleting factor (CVF)". Osipov AV, Mordvintsev DY, Starkov VG, Galebskaya LV, Ryumina EV, Bel'tyukov PP, Kozlov LV, Romanov SV, Doljansky Y, Tsetlin VI, Utkin YN.
 Links
Product code L8117-100UG 
Product name CVFm (Cobra Venom Factor) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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