L8106-100UG - DENDROTOXIN (Alpha-)
(Syn. : Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin, Alpha-DTX)
(Syn. : Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin, Alpha-DTX)
DENDROTOXIN (Alpha-) | Product ID | L8106-100UG |
| Name | DENDROTOXIN (Alpha-) |
| Molecular formula | |
| Description |
59-amino acid peptide with 3 disulfide bridges , from Dendroaspis angusticeps snake venom. |
| Biological activity | A toxin which facilitates synaptic transmission at the neuromuscular junction and has been shown to block a 4-AP-sensitive, inactivating, voltage-gated K+ current. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 147.00 | ||
| 5 Unité(s) | 588.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8106-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8106-100UG | Molecular weight | 7,071 Da |
| Product name | DENDROTOXIN (Alpha-) | Physical form | |
| CAS No. | 74504-53-3 | Melting point | |
| RTECS | Solubility | In water and saline | |
| UNIPROT | P00980 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | > 78% (HPLC) | ||
| Toxicity(LD50) | |||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable in freeze-dried state. In solution, keep at -20°C. |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8106-100UG |
| Product name | DENDROTOXIN (Alpha-) |
- Harvey et al., "Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctionnal blocking toxins." Br. J. Pharmacol. 1982 77:153-161
- Halliwell et al., "Central action of Dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors." Proc. Natl. Acad. Sci. USA (1986). 83:493-497
- Stansfeld et al., "4-Aminopyridine and Dendrotoxin induce repetitive firing in rat visceral sensory neurons by blocking slowly inactivating outward current." Neurosci. Lett.(1986). 64:299-304
- Harvey et al., "Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps: a neurotoxin that enhances acetylcholine release at neuromuscular junctions." Naunyn-Schmiedeberg's Arch. Pharmacol. (1980). 312:1-6
- Benishin et al., Molecular Pharmacology(1988). 34:152-159
Links
| Product code | L8106-100UG |
| Product name | DENDROTOXIN (Alpha-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
