Venom of
Crotalus durissus ruruimaHOGE 1966
Crotalus durissus ruruimaHOGE 1966
SNAKE VENOMS | Product ID | L1232 |
| Name | Crotalus durissus ruruima |
| Common Name(s) | Mount Roraima rattlesnake |
| Origin | Venezuela, adjacent Brazil |
| Purity | 100% |
| Form | Lyophilized powder |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 100 mg | 273.00 | ||
| 500 mg | 1 023.75 | ||
| 1 g | 1 638.00 | ||
| For quotation of big quantities, please Contact us | |||
Species Protection Status
| CITES | III (Ref. : UNEP-WCNC) |
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| EU | ||
| France | Protected |
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L1232 : unit price : free of charge |
Related Links
| See also |
The UNEP-WCNC species Database (http://www.unep-wcmc.org) ITIS : Integrated Taxonomic Information System (http://www.itis.gov) Search Crotalus durissus ruruima with 
Search Crotalus durissus ruruima with  PubMed
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| Bibliography | 1: Pucca MB, Bernarde PS, Rocha AM, Viana PF, Farias RES, Cerni FA, Oliveira IS, Ferreira IG, Sandri EA, Sachett J, Wen FH, Sampaio V, Laustsen AH, Sartim MA, Monteiro WM. Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology. Front Immunol. 2021 Jun 8;12:659515. doi: 10.3389/fimmu.2021.659515. PMID: 34168642; PMCID: PMC8219050. 2: de Carvalho AEZ, Giannotti K, Junior EL, Matsubara M, Santos MCD, Fortes-Dias CL, Teixeira C. Crotalus durissus ruruima Snake Venom and a Phospholipase A2 Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators. J Immunol Res. 2019 Nov 4;2019:2745286. doi: 10.1155/2019/2745286. PMID: 31781674; PMCID: PMC6875421. 3: Asato MS, Cruz Carbonell RC, Martins AG, Mendonça de Moraes C, Chávez- Olórtegui C, Apolonia da Costa Gadelha M, Pereira de Oliveira Pardal P. Envenoming by the rattlesnake Crotalus durissus ruruima in the state of roraima, Brazil. Toxicon X. 2020 Oct 22;8:100061. doi: 10.1016/j.toxcx.2020.100061. PMID: 33145491; PMCID: PMC7591384. 4: Colombini M, Rocha AM, Freitas-de-Sousa LA, Chaves AFA, Serrano SMT, Souza VC, Viala VL, Junqueira-Azevedo ILM, Cerni FA, Sartim MA, Sachett JAG, Monteiro WM, Grazziotin FG, Wen FH, Pucca MB, Moura-da-Silva AM. Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. PLoS Negl Trop Dis. 2025 Aug 1;19(8):e0013296. doi: 10.1371/journal.pntd.0013296. PMID: 40749023; PMCID: PMC12327661. 5: Cavalcante WL, Ponce-Soto LA, Marangoni S, Gallacci M. Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis. Toxicon. 2015 Mar;96:46-9. doi: 10.1016/j.toxicon.2015.01.006. Epub 2015 Jan 15. PMID: 25598498. 6: Muniz EG, Sano-Martins IS, Saraiva MDGG, Magno ES, Oliveira SS. Ability of brazilian Bothrops-Lachesis-Crotalus antivenom in neutralizing some biological activities of Crotalus durissus ruruima rattlesnake venom. Toxicon. 2025 Jan;254:108211. doi: 10.1016/j.toxicon.2024.108211. Epub 2024 Dec 17. PMID: 39674409. 7: Tasima LJ, Lima EOV, Kavazoi VK, Silveira GPM, Vidueiros JP, Grego KF, Tanaka-Azevedo AM. Ontogenetic influence in Crotalus durissus ruruima snake venom: an intermediate between north and south venom pattern of rattlesnake. Toxicon. 2025 Oct;265:108467. doi: 10.1016/j.toxicon.2025.108467. Epub 2025 Jul 3. PMID: 40614827. 8: Dos-Santos MC, Assis EB, Moreira TD, Pinheiro J, Fortes-Dias CL. Individual venom variability in Crotalus durissus ruruima snakes, a subspecies of Crotalus durissus from the Amazonian region. Toxicon. 2005 Dec 15;46(8):958-61. doi: 10.1016/j.toxicon.2005.06.008. Epub 2005 Nov 2. PMID: 16269162. 9: Diz Filho EB, Marangoni S, Toyama DO, Fagundes FH, Oliveira SC, Fonseca FV, Calgarotto AK, Joazeiro PP, Toyama MH. Enzymatic and structural characterization of new PLA2 isoform isolated from white venom of Crotalus durissus ruruima. Toxicon. 2009 Jan;53(1):104-14. doi: 10.1016/j.toxicon.2008.10.021. Epub 2008 Oct 26. PMID: 19013478. 10: Demico PJ, Oliveira IN, Proença-Hirata VS, Dias SR, Ghirotti HA, Silva EO, Giometti IC, Pacagnelli FL, Torres-Bonilla KA, Hyslop S, Galizio NC, de Morais- Zani K, Pucca MB, Rocha AM, Maciel JB, Sartim MA, Monteiro WM, Floriano RS. Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of Crotalus durissus ruruima Venom and Antivenom Efficacy. Pharmaceuticals (Basel). 2025 Jan 6;18(1):54. doi: 10.3390/ph18010054. PMID: 39861117; PMCID: PMC11768973. 11: Calvete JJ, Sanz L, Cid P, de la Torre P, Flores-Díaz M, Dos Santos MC, Borges A, Bremo A, Angulo Y, Lomonte B, Alape-Girón A, Gutiérrez JM. Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America. J Proteome Res. 2010 Jan;9(1):528-44. doi: 10.1021/pr9008749. PMID: 19863078. 12: Dos-Santos MC, Arroyo C, Solano S, Herrera M, Villalta M, Segura A, Estrada R, Gutiérrez JM, León G. Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: implications for the production of polyspecific snake antivenoms. Toxicon. 2011 Feb;57(2):237-43. doi: 10.1016/j.toxicon.2010.11.016. Epub 2010 Dec 2. PMID: 21130107. 13: Fonseca FV, Baldissera L Jr, Camargo EA, Antunes E, Diz-Filho EB, Corrêa AG, Beriam LO, Toyama DO, Cotrim CA, Alvin J Jr, Toyama MH. Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor. Toxicon. 2010 Jul;55(8):1527-30. doi: 10.1016/j.toxicon.2010.03.004. Epub 2010 Mar 16. Erratum in: Toxicon. 2011 Nov;58(6-7):614. Alvin, Joel Jr [added]. PMID: 20223257. 14: Ponce-Soto LA, Baldasso PA, Romero-Vargas FF, Winck FV, Novello JC, Marangoni S. Biochemical, pharmacological and structural characterization of two PLA2 isoforms Cdr-12 and Cdr-13 from Crotalus durissus ruruima snake venom. Protein J. 2007 Jan;26(1):39-49. doi: 10.1007/s10930-006-9042-3. PMID: 17203396. 15: Maciel JB, Nardini V, Carvalho NS, Trabuco AC, da Silva VCPR, Maciel AR, Viana PF, Pucca MB, Koolen HHF, Monteiro W, Sartim MA, Faccioli LH. Lipidomics of Bothrops atrox and Crotalus durissus ruruima venoms, the two major viperids involved in human envenomings in the Brazilian Amazon. Arch Toxicol. 2026 Jan;100(1):355-366. doi: 10.1007/s00204-025-04200-2. Epub 2025 Sep 29. PMID: 41023201. 16: Dos Santos MC, Ferreira LC, Da Silva WD, Furtado MF. Caracterizacion de las actividades biologicas de los venenos 'amarillo' y 'blanco' de Crotalus durissus ruruima comparados con el veneno de Crotalus durissus terrificus. Poder neutralizante de los antivenenos frente a los venenos de Crotalus durissus ruruima [Characterization of the biological activities of the 'yellow' and 'white' venoms from Crotalus durissus ruruima compared with the Crotalus durissus terrificus venom. Neutralizing activity of Crotalus durissus ruruima antivenins]. Toxicon. 1993 Nov;31(11):1459-69. Spanish. doi: 10.1016/0041-0101(93)90211-z. PMID: 8310446. 17: Molina Molina DA, Guerra-Duarte C, Costal-Oliveira F, Almeida Rocha E, Rego Rodrigues C, Machado-de-Ávila RA, Soccol VT, Chávez-Olórtegui C. Engineered protein containing crotoxin epitopes induces neutralizing antibodies in immunized rabbits. Mol Immunol. 2020 Mar;119:144-153. doi: 10.1016/j.molimm.2020.01.012. Epub 2020 Feb 2. PMID: 32023500. 18: Pereañez JA, Núñez V, Huancahuire-Vega S, Marangoni S, Ponce-Soto LA. Biochemical and biological characterization of a PLA2 from crotoxin complex of Crotalus durissus cumanensis. Toxicon. 2009 Apr;53(5):534-42. doi: 10.1016/j.toxicon.2009.01.021. PMID: 19673100. 19: Felicori LF, Chávez-Olórtegui C, Sánchez EF. Specific identification of Lachesis muta muta snake venom using antibodies against the plasminogen activator enzyme, LV-PA. Toxicon. 2005 May;45(6):803-6. doi: 10.1016/j.toxicon.2004.12.003. PMID: 15804530. |
Taxonomic Classification
- Class : Reptilia
- Order : Squamata
- Suborder : Serpentes
- Family : Viperidae
- Subfamily : Crotalinae
- Genus : Crotalus
